Katherine D Watson

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The large-scale use of chemical warfare agents first occurred during World War I (the "chemists' war"), and was thereafter repeated at irregular intervals, most recently during the Iran-Iraq conflict of the 1980s. There was consequently a possibility that chemical weapons might be used in the Gulf war. The threat posed by terrorist groups became evident in(More)
Acquisition of the epithelial-mesenchymal transition (EMT) tumor phenotype is associated with impaired chemotherapeutic delivery and a poor prognosis. In this study, we investigated the application of therapeutic ultrasound methods available in the clinic to increase nanotherapeutic particle accumulation in epithelial and EMT tumors by labeling particles(More)
Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an important role in vascular development, remodeling, and pathologic angiogenesis. Here we investigated the role of ALK1 in angiogenesis in the context of common proangiogenic factors [PAF; VEGF-A and basic fibroblast growth factor (bFGF)]. We observed that PAFs(More)
Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not been characterized. We tested the hypothesis that VEGF-C-induced activation of VEGF receptor (VEGFR)-3 increases lymphatic pump output. We examined the in vivo pump activity of rat mesenteric(More)
Previous studies in hibernating species have characterized two forms of neural plasticity in the hippocampus, long-term potentiation (LTP) and its reversal, depotentiation, but not de novo long-term depression (LTD), which is also associated with memory formation. Studies have also shown that histamine injected into the hippocampus prolonged hibernation(More)
BACKGROUND Immune-mediated polyarthopathy (IMPA) is common in dogs, and is monitored by serial arthrocenteses. HYPOTHESIS/OBJECTIVES Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and CXCL8 (interleukin-8) would serve as noninvasive markers of joint inflammation in IMPA. ANIMALS Nine client-owned dogs with idiopathic IMPA; 6 healthy controls. (More)
hardly more than a shadow." This sentimental view of death from tuberculosis reappears frequently in this monograph. Dormandy has been influenced by Rene and Jean Dubos' widely-read and often cited book, The white plague: tuberculosis, man and society. Although Dormandy's book is longer and more comprehensive, some of the stories of dying consumptives will(More)
Objectives Thalamotomy of the ventral intermediate nucleus (VIM) is effective in alleviating medication resistant tremor in patients with essential tremor (ET) and Parkinson's disease (PD). MRI guided Focused Ultra-sound (MRgFUS) is an innovative technology that enables non-invasive thalamotomy via thermal ablation. Methods Thirty eight ET and PD patients(More)
Sir-The advantage of carboplatin in tumours known to demonstrate cisplatinum sensitivity is the prospect of reduced nephro-and ototoxicity. Sleijfer et al. (1989), however, suggested from data derived in adults receiving carboplatin at a dose of 400 mg m-2 that significant reductions of GFR occur. This is contrary to general clinical experience in(More)
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