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Receptor tyrosine kinases and Notch are crucial for tube formation and branching morphogenesis in many systems, but the specific cellular processes that require signaling are poorly understood. Here we describe sequential roles for Notch and Epidermal growth factor (EGF)-Ras-ERK signaling in the development of epithelial tube cells in the C. elegans(More)
The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes to chemotherapy resistance and tumor relapse. However, clinically applicable inhibitors of ALDH activity have not been reported. There is evidence to suggest that epigenetic regulation of(More)
Walther Flemming and other biologists knew that a complex of genetic material and pro-teins? what we now refer to as chromatin? condenses during cell division. In fact, it was the condensed nature of mitotic chromosomes that enabled their visualization under a standard light microscope. Fast forward to the mid 20th century during the era of molecular(More)
The transition of Drosophila third instar larvae from feeding, photo-phobic foragers to non-feeding, photo-neutral wanderers is a classic behavioral switch that precedes pupariation. The neuronal network responsible for this behavior has recently begun to be defined. Previous genetic analyses have identified signaling components for food and light sensory(More)
During mitosis, the genome is silent. When cells exit mitosis and re-enter the cell cycle, how does the tran-scriptional program of a differentiated cell become reactivated faithfully and in a timely manner? We previously found that in undifferentiated progenitor cells in the early embryo, the competence to activate transcription-ally silent genes is(More)
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