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Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations.
TLDR
A warfarin-dosing algorithm for a multi-ethnic population that predicts the best dose for stable anticoagulation andMinor improvements in algorithms can be observed with the inclusion of ethnicity and more CYP2C9 and VKORC1 SNPs as variables.
A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
Genetic ancestry influences asthma susceptibility and lung function among Latinos.
Race, ethnicity and social class and the complex etiologies of asthma.
Asthma is a common but complex respiratory disease caused by the interaction of genetic and environmental factors. Significant racial and ethnic disparities in prevalence, mortality and drug response
Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRbeta(R320H): a tailor-made approach toward the treatment of resistance to thyroid hormone.
TLDR
Two new series of tetrazole and thiazolidinedione based ligands were evaluated for their ability to recover potency and efficacy to three of the most common RTH-associated mutants, TRbeta (R320C), TRbeta(R320H), and TR beta(R316H), in cell based assays.
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