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UNLABELLED These studies investigated whether anatomical measures could separate phonologically-based reading disability (PD) from nonphonologically-based learning disabilities such as specific language impairment (SLI). In a previous study. four brain measures (cerebral asymmetry. summed planum temporale and parietale asymmetry, anterior cerebellar(More)
Men outperform women on the Iowa Gambling Task (IGT; A. Bechara, H. Damasio, D. Tranel, & A. R. Damasio, 1997). In this study, the authors show that sex differences are not due to differences in general emotional arousal or the abilities to calculate or reverse responses. Imaging studies have shown that, during the IGT, men increase activity in the right(More)
Males outscore females on the original version of the Iowa Gambling Task (IGT). This may be due to differential regional prefrontal cortical activation by males and females during the task. PET imagery indicates increased activation in dorsolateral (DL) prefrontal cortex (PFC) in males and in medial orbital (ORB) PFC in females. A recent study reported that(More)
BACKGROUND AND PURPOSE Symptomatic vertebrobasilar disease (VBD) carries a high risk of recurrent stroke. We sought to determine whether a management algorithm consisting of quantitative hemodynamic assessment could stratify stroke risk and guide the need for intervention. METHODS All patients with symptomatic VBD at our institution are evaluated by a(More)
PURPOSE The phosphoinositide 3-kinase (PI3K) pathway is known to play an active role in many malignancies. The role of PI3K inhibition in the treatment of lymphomas has not been fully delineated. We sought to identify a role for therapeutic PI3K inhibition across a range of B-cell lymphomas. EXPERIMENTAL DESIGN We selected three small molecule inhibitors(More)
The prognosis of AML is poor, highlighting the need for novel treatments. Hypomethylating agents, including decitabine are used to treat elderly AML patients with relative success. Targeting nuclear exporter receptors (Exportin 1, XPO1) is a novel approach to restore tumor suppressor (TS) function in AML. Here, we show that sequential treatment of AML(More)
Arachidonic acid is metabolized to four regioisomeric epoxyeicosatrienoic acids (EETs) by cytochrome P-450. 5,6-, 8,9-, 11,12-, and 14,15-EET are equipotent in relaxing bovine coronary arteries (BCAs). Vasorelaxant effects of EETs are nonselectively antagonized by 14,15-epoxyeicosa-5(Z)-enoic acid. The 11,12-EET analogs,(More)
As the Association of Oncology Social Work celebrates its 25th year, we pause to reflect on the many historical threads that contributed to its development and hear from each of the presidents who helped create the organization, as we know it today. Set within hospitals, medical social work was born in the early 20th century. In the 1940s medical social(More)
Translational Relevance: Lymphomas are a common group of malignancies with a high degree of clinical and molecular heterogeneity. This poses a major problem in the effective identification of new therapies and in the design of new clinical trials. Current approaches to preclinical testing frequently rely on small numbers of lymphoma cell lines from(More)
Purpose: The phosphoinositide 3-kinase (PI3K) pathway is known to play an active role in many malignancies. The role of PI3K inhibition in the treatment of lymphomas has not been fully delineated. We sought to identify a role for therapeutic PI3K inhibition across a range of B-cell lymphomas. Experimental Design: We selected three small molecule inhibitors(More)