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OBJECTIVE To identify whether measures of energy intake and expenditure predict excessive weight gain over time in children and to describe how these measures relate to similar measures in parents. DESIGN Prospective, descriptive study over 12 months with no intervention. SETTING University teaching hospital. SUBJECTS Children aged between 6.0 and 9.0(More)
BACKGROUND Despite the popularity of low-glycemic index (GI) and high-protein diets, to our knowledge no randomized, controlled trials have systematically compared their relative effects on weight loss and cardiovascular risk. METHODS A total of 129 overweight or obese young adults (body mass index, > or =25 [calculated as weight in kilograms divided by(More)
OBJECTIVES To compare the resting metabolic rate (RMR) between diabetic and nondiabetic obese subjects and to develop a predictive equation of RMR for these subjects. RESEARCH METHODS AND PROCEDURES Obese adults (1088; mean age = 44.9 +/- 12.7 years) with BMI > or = 35 kg/m2 (mean BMI = 46.4 +/- 8.4 kg/m2) were recruited. One hundred forty-two subjects(More)
Weight loss can be achieved by any means of energy restriction, but the challenge is to achieve sustainable weight loss and prevent weight "creep" without increasing the risk of chronic disease. The modest success of low fat diets has prompted research on alternative dietary strategies, including high protein diets and low glycemic index (GI) diets.(More)
CONTEXT Hyperinsulinism and its associated metabolic abnormalities, including diabetes mellitus (DM), have been reported in long-term survivors of childhood cancer, mainly after bone marrow transplant (BMT); however, the predisposing factors are unclear, and early markers have not been identified. METHODS The prevalence of overweight/obesity, abdominal(More)
Myotonic dystrophy (MD) is a systemic genetic disorder predominantly affecting musculature. Although endocrine disturbances have been described, data relating to thyroid gland involvement are sparse and conflicting. To further investigate this aspect, twenty MD patients and twenty age-and sex-matched controls were studied. All were clinically euthyroid and(More)
The prevalence of childhood obesity is increasing and there are a number of theoretical reasons as to why intervention may be more effective in childhood. There are certain risk times for the development of obesity in childhood, which provide a basis for targeted intervention. In addition, tracking data supports the persistence of obesity, at least in later(More)
BACKGROUND Concomitant with the rise in childhood obesity there has been a significant increase in the number of adolescents with clinical features of insulin resistance and prediabetes. Clinical insulin resistance and prediabetes are likely to progress to type 2 diabetes and early atherosclerosis if not targeted for early intervention. There are no(More)
OBJECTIVES To assess the implications of variation in Metabolic Syndrome (MS) definition (biochemical and anthropometric indicators) on MS prevalence estimates in a population of overweight and mildly obese children. DESIGN Cross-sectional study. SUBJECTS Ninety-nine (64 girls) overweight or mildly obese, but otherwise healthy, pre-pubertal 6-9-year(More)