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CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

• Keiran Sm Smalley, Min Xiao, +8 authors Meenhard Herlyn
• Oncogene
• 2009

Here, we identify a panel of melanoma lines with non-V600E mutations in BRAF. These G469E- and D594G-mutated melanomas were found to exhibit constitutive levels of phospho-extracellular… (More)

The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes.

• Hong Jen Yu, Ronan McDaid, +12 authors Xiaowei Xu
• The American journal of pathology
• 2009

Melanocytic nevi frequently harbor oncogenic BRAF mutations, but only a minority progress to melanoma. In human melanocytes, persistent BRAF(V600E) expression triggers oncogene-induced senescence,… (More)

Tumorigenesis and Neoplastic Progression The Role of BRAF Mutation and p 53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes

• Hongtao Yu, Ronan McDaid, +12 authors X Xu
• 2010

Melanocytic nevi frequently harbor oncogenic BRAF mutations, but only a minority progress to melanoma. In human melanocytes, persistent BRAF expression triggers oncogene-induced senescence, which… (More)

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