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G protein-coupled receptor (GPCR) sequestration to endosomes is proposed to be the mechanism by which G protein-coupled receptor kinase (GRK)-phosphorylated receptors are dephosphorylated and(More)
NATURE REVIEWS | DRUG DISCOVERY VOLUME 3 | OCTOBER 2004 | 823 More than a decade ago, with sequences of newly cloned ‘disease genes’ in hand, high hopes were placed on the direct intervention of(More)
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