Katharine E Hartnack

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BACKGROUND Electroencephalogram patterns observed during sedation with dexmedetomidine appear similar to those observed during general anesthesia with propofol. This is evident with the occurrence of slow (0.1 to 1 Hz), delta (1 to 4 Hz), propofol-induced alpha (8 to 12 Hz), and dexmedetomidine-induced spindle (12 to 16 Hz) oscillations. However, these(More)
BACKGROUND The neural mechanisms of anesthetic vapors have not been studied in depth. However, modeling and experimental studies on the intravenous anesthetic propofol indicate that potentiation of γ-aminobutyric acid receptors leads to a state of thalamocortical synchrony, observed as coherent frontal alpha oscillations, associated with unconsciousness.(More)
OBJECTIVE Ketamine is a widely used drug with clinical and research applications, and also known to be used as a recreational drug. Ketamine produces conspicuous changes in the electrocorticographic (ECoG) signals observed both in humans and rodents. In rodents, the intracranial ECoG displays a high-frequency oscillation (HFO) which power is modulated(More)
  • Citation Akeju, Kara J Oluwaseun, M Pavone, Rafael Brandon Westover, Michael J Vazquez, Priscilla G Prerau +17 others
  • 2015
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Background—Electroencephalogram patterns observed during sedation with dexmedetomidine appear similar to those observed during general anesthesia with propofol. This is evident with the occurrence of slow (0.1–1 Hz), delta (1–4(More)
  • Citation Akeju, M Oluwaseun, Kara J Brandon Westover, Aaron L Pavone, Katharine E Sampson, Emery N Hartnack +9 others
  • 2014
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Background—The neural mechanisms of anesthetic vapors have not been studied in depth. However, modeling and experimental studies on the intravenous anesthetic propofol indicate that potentiation of γ-Aminobutyric acid receptors(More)
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