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Genetically modified mice have been a major source of information about the molecular control of Schwann-cell myelin formation, and the role of β-neuregulin 1 (NRG1) in this process in vivo. In vitro, on the other hand, Schwann cells from rats have been used in most analyses of the signaling pathways involved in myelination. To correlate more effectively in… (More)
A new method is presented for measuring swelling or rat paw edema in inflammation induced by carrageenin injection. This technique is compared to other widely used ones. A spring-loaded dial indicator produces results that are accurate, precise and reproducible. It is recommended for investigators seeking the advantages of a noninvasive, low cost, rapid… (More)
Injections of alpha-1-acid-glycoprotein along with urate crystals induced less footpad swelling than that caused by injections of urate crystals alone. This anti-inflammatory action of acid-glycoprotein is considered to add further support to the hypothesis that perturbations in acute phase proteins are protective.
BACKGROUND Cediranib, an oral pan-vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor, failed to show benefit over lomustine in relapsed glioblastoma. One resistance mechanism for cediranib is up-regulation of epidermal growth factor receptor (EGFR). This study aimed to determine if dual therapy with cediranib and the oral EGFR… (More)