Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
- Katharina Minke, P. Staib, K. Kreuzer
- BiologyEuropean Journal of Haematology
- 1 March 2009
The data demonstrate that targeting this pathway seems to be an innovative approach in the treatment of AML, and substantially decrease expression of CTNNB1/LEF1 target genes c‐myc, cyclin D1 and survivin, proving the specificity of the substances.
Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo
- R. Gandhirajan, P. Staib, K. Kreuzer
- Biology, Medicine
- 1 April 2010
Inhibition of lef-1 by siRNA leads to increased apoptosis of CLL cells and inhibited proliferation of JVM-3 cell lines, demonstrating that targeting le f-1 is a new and selective therapeutic approach in CLL.
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo.
- R. Gandhirajan, P. Staib, K. Kreuzer
- Biology, MedicineNeoplasia
- 2010
It is demonstrated that targeting lef-1 is a new and selective therapeutic approach in CLL and CGP049090 or PKF115-584 may be attractive compounds for C LL and other malignancies that deserve further (pre)clinical evaluation.
High-pressure double stage homogenization processes: Influences of plant setup on oil droplet size
- M. Schlender, Katharina Minke, Burkard Spiegel, H. Schuchmann
- Physics
- 28 July 2015
Sono-chemiluminescence (SCL) in a high-pressure double stage homogenization processes
- M. Schlender, Katharina Minke, H. Schuchmann
- Engineering
- 13 March 2016
Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells
- R. Gandhirajan, P. Staib, K. Kreuzer
- Biology, Medicine
- 2010
Inhibition of lef-1 by siRNA leads to increased apoptosis of CLL cells and inhibited proliferation of JVM-3 cell lines, and it is demonstrated that targeting le f-1 is a new and selective therapeutic approach in CLL.
Synthesis of triacetonediamine by reductive amination starting from triacetonediamine and its derivatives
- Katharina Minke, Benjamin Willy
- Chemistry
- 7 July 2016
The present invention relates to a method, which is converted to 4-amino-2,2,6,6-tetramethylpiperidine or a derivative thereof with a carbonyl compound in a reductive amination.
Small Molecule Inhibitors of Wnt/ β -Catenin / Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo 1,2
- R. Gandhirajan, P. Staib, K. Kreuzer
- Biology, Medicine
- 2010
Inhibition of lef-1 by siRNA leads to increased apoptosis of CLL cells and inhibited proliferation of JVM-3 cell lines, demonstrating that targeting le f-1 is a new and selective therapeutic approach in CLL.