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  • K M Picker
  • 2001
The purpose of this study was to complete information on elastic recovery during a compression cycle by measuring the expansion of the tablet after ejection, and thus, to measure the whole recovery process, which means the time dependency of elastic recovery. Two methods were applied: manual measurement by a micrometer screw, and a continuous measurement by(More)
Carrageenans were analysed in mixture with polymorphic drugs to test their potential for minimising polymorphic or pseudopolymorphic transitions, which are induced by the tableting process. The kappa-carrageenans Gelcarin GP-812 NF and Gelcarin GP-911 NF and the iota-carrageenan Gelcarin GP-379 NF were tested in comparison to the well-known tableting(More)
  • K M Picker
  • 1999
Carrageenans can be used as excipients for controlled-release tablets. The aim of this study was to determine their compaction and consolidation behavior to prove their usefulness for tableting. The Carr indices of the three carrangeenans, two kappa-carrageenans(Gelcarin GP-812 NF and GP-911 NF) and one tau-carrageenan (Gelcarin GP-379 NF), indicate that(More)
  • K M Picker
  • 1999
The modulation of tableting and release behavior of combinations of kappa-carrageenan Gelcarin((R)) GP 911 NF and microcrystalline cellulose (MCC) Avicel((R)) PH 101 has been evaluated. Graded binary mixtures were tableted to a maximum relative density of 0.850 at the maximum displacement of the upper punch. Additionally, ternary mixtures with the same(More)
  • K M Picker
  • 2000
A new analytical method - the automatic micrometer screw - has been established to measure the edge height of tablets. The equipment offers many advantages compared with other methods. The precision is slightly increased compared to the traditional micrometer screw and the measurement with a small punch and a linear voltage transducer. No longer any touch(More)
  • K M Picker
  • 2000
The purpose of the study was to develop a new three-dimensional model using force, time and displacement to characterize the densification behavior of tableting materials. Normalized time (x), displacement converted to ln(1/1 - D(rel)) according to Heckel (y) and force presented as pressure (z) were used to plot a graph. A twisted plane was fitted to this(More)
The aim of this study was to confirm the hypothesis that tableting using excipients with greater elastic deformation results in improved performance of pressure-sensitive drugs relative to the excipients with low elastic deformation. Tableting with highly elastic deforming excipients and the resultant minimization of the process damage is referred to in(More)
  • K M Picker
  • 1999
Carrageenans are hydrocolloids in the rubbery state at standard conditions. They are useful excipients for controlled-release tablets. Three carrageenans, two kappa-carrageenans (Gelcarin GP-812 NF and GP-911 NF) and one iota-carrageenan (Gelcarin GP-379 NF), are analyzed regarding their release behavior in combination with sorption, swelling, and rheology.(More)
The purpose of this study was to characterize the thermal properties of microcrystalline cellulose (MCC) and to investigate the influence of water on these properties. Differential scanning calorimetry (DSC), modulated temperature differential scanning calorimetry (MTDSC), thermomechanical analysis (TMA), and scanning electron microscopy (SEM) were used to(More)
The aim of this research was to investigate the elastic-plastic deformation behavior of the cellulose ethers hydroxypropylmethylcellulose (HPMC), hydroxyethylmethylcellulose (HEMC), and sodium carboxymethylcellulose (NaCMC) at relative humidities (RH) of 38, 57, and 75% and assess how the release of drugs embedded in such matrices is affected by the inner(More)