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Alport syndrome inevitably leads to end-stage renal disease and there are no therapies known to improve outcome. Here we determined whether angiotensin-converting enzyme inhibitors can delay time to dialysis and improve life expectancy in three generations of Alport families. Patients were categorized by renal function at the initiation of therapy and(More)
The objective of this study was to investigate potential associations of Alzheimer's disease risk single nucleotide polymorphisms (SNP) with disease progression. SNP in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, and TNK1 were determined in 40 Alzheimer's disease patients who were observed for 2 to 3 years. Annual Mini Mental(More)
The use of trait-based approaches to detect effects of land use and climate change on terrestrial plant and aquatic phytoplankton communities is increasing, but such a framework is still needed for benthic stream algae. Here we present a conceptual framework of morphological, physiological, behavioural and life-history traits relating to resource(More)
We studied here the clinical course of heterozygous carriers of X-linked Alport syndrome and a subgroup of patients with thin basement membrane disease due to heterozygous autosomal recessive Alport mutations whose prognosis may be worse than formerly thought. We analyzed 234 Alport carriers, including 29 with autosomal recessive mutations. Using(More)
PURPOSE The clinical performance of three- and four-unit fixed partial dentures (FPDs) with frameworks made of yttria partially stabilized zirconia was determined after a mean observational period of 84 months. MATERIALS AND METHODS Seventy-five patients were treated with 99 posterior FPDs. Fifty-one specimens were veneered with an experimental ceramic(More)
OBJECTIVES Evaluation of the prevalence rates of periimplant mucositis and periimplantitis in partially edentulous patients in a private dental practice. MATERIAL AND METHODS The data of 89 patients were collected (52 female, 37 male, age at time of implant placement: 51.8 ± 10.3 years). All patients had been treated with dental implants of the same type(More)
BACKGROUND/OBJECTIVE Apolipoprotein E plays a role in the pathogenesis of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) and plasma level alterations have been reported in AD patients. In search of a potential biomarker, which would be predictive of cognitive, functional, or motor decline, we analyzed CSF apolipoprotein E (ApoE) levels of AD patients(More)
Changes to land use affect streams through nutrient enrichment, increased inputs of sediment and, where riparian vegetation has been removed, raised water temperature. We manipulated all three stressors in experimental streamside channels for 30 days and determined the individual and pair-wise combined effects on benthic invertebrate and algal communities(More)
This study evaluated the effect of different parameters on the marginal precision of CAD/CAM-fabricated zirconia copings. Specimens(n=60) were fabricated with two different scanners and two milling systems. The copings were evaluated with respect to their mean and average maximum marginal gaps. A two-way analysis of variance (ANOVA) (α=0.05) was used to(More)
BACKGROUND AND OBJECTIVES Patients with the hereditary disease Alport syndrome commonly require renal replacement therapy (RRT) in the second or third decade of life. This study compared age at onset of RRT, renal allograft, and patient survival in men with Alport syndrome receiving various forms of RRT (peritoneal dialysis, hemodialysis, or(More)