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Absorption of ipratropium and l-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters.
- Ghaith Aljayyoussi, Daniel F. Price, +4 authors C. Morris
- Chemistry, Medicine
- International journal of pharmaceutics
- 30 December 2015
The organic cation transporters OCT and OCTN have been reported to play a significant role in the cellular uptake of substrates within in vitro lung cells. However, no studies to date have… Expand
Spatial expression and functionality of drug transporters in the intact lung: objectives for further research.
- M. Gumbleton, Ghaith Aljayyoussi, +4 authors M. Smith
- Biology, Medicine
- Advanced drug delivery reviews
This commentary provides a background appraising evidence in the intact lung on the spatial expression of drug transporters and, where available, evidence in the intact lung of the impact, or… Expand