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Exosomes emerge as central 3'-->5' RNA processing and degradation machineries in eukaryotes and archaea. We determined crystal structures of two 230 kDa nine subunit archaeal exosome isoforms. Both exosome isoforms contain a hexameric ring of RNase phosphorolytic (PH) domain subunits with a central chamber. Tungstate soaks identified three phosphorolytic… (More)
From a socio-political revolution perspective we review Twitter-related literature included in top peer-reviewed journals and conferences, and build up a comprehensive picture. Based on this we identify empirical and design-oriented research needs.