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UNLABELLED Although progress in Chlamydia genetics has been rapid, genomic modification has previously been limited to point mutations and group II intron insertions which truncate protein products. The bacterium has thus far been intractable to gene deletion or more-complex genomic integrations such as allelic exchange. Herein, we present a novel suicide(More)
Type I IFNs are induced during microbial infections and have well-characterized antiviral activities. TRAF3 is a signaling molecule crucial for type I IFN production and, therefore, represents a potential target for disarming immune responses. Chlamydia pneumoniae is a human pathogen that primarily infects respiratory epithelial cells; the onset of symptoms(More)
A disadvantage in Q fever diagnostics and research is the insensitive and difficult culture of Coxiella burnetii. This intracellular organism can only be isolated using embryonated eggs, animal hosts, or mammalian cell culture. In consequence, it has only been possible to isolate a few strains from human patients. Here, we describe the first isolation of C.(More)
Chlamydia pneumoniae is an obligate intra-cellular parasite which infects mucosal surfaces of the human respiratory tract causing sinusitis, pharyngitis, bronchitis, and pneumonia. Although the bacterium causes acute disease, mildly symptomatic, asymptomatic, or unrecognized infections are most common (Kuo et al., 1995). C. pneumoniae infections are(More)
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