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A fuzzy rule-based decision support system (DSS) is presented for the diagnosis of coronary artery disease (CAD). The system is automatically generated from an initial annotated dataset, using a four stage methodology: 1) induction of a decision tree from the data; 2) extraction of a set of rules from the decision tree, in disjunctive normal form and(More)
In this work, we present a platform for the development of multiscale patient-specific artery and atherogenesis models. The platform, called ARTool, integrates technologies of 3-D image reconstruction from various image modalities, blood flow and biological models of mass transfer, plaque characterization, and plaque growth. Patient images are acquired for(More)
BACKGROUND Type 2 diabetes mellitus (T2DM) is independently associated with an increased risk for cardiovascular diseases that is primarily due to the early development of advanced atherosclerotic vascular changes. The aim of our study was to investigate the predictors of vascular dysfunction in T2DM patients. METHODS We studied 165 T2DM patients without(More)
Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for the simulation. Eight coronary arteries (lumen and outer(More)
This paper introduces an automated methodology for the extraction of fetal heart rate from cutaneous potential abdominal electrocardiogram (abdECG) recordings. A three-stage methodology is proposed. Having the initial recording, which consists of a small number of abdECG leads in the first stage, the maternal R-peaks and fiducial points (QRS onset and(More)
Cardiovascular disease, including coronary artery disease, stroke and peripheral vascular disease, is the leading cause of death among women. Vascular endothelial dysfunction is an early marker of atherosclerosis. Women with premature ovarian failure (or premature menopause) present an increased risk for cardiovascular disease, which might be attributed to(More)
A three-stage method for fetal heart rate extraction, from abdominal ECG recordings, is proposed. In the first stage the maternal R-peaks and fiducial points (QRS onset and offset) are detected, using time-frequency analysis, and the maternal QRS complexes are eliminated. The second stage locates the positions of the candidate fetal R-peaks, using complex(More)
BACKGROUND Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on novel echocardiographic indices of left ventricular (LV) diastolic function in DM2 patients with LV diastolic dysfunction (LVDD). METHODS(More)
Intravascular ultrasound (IVUS) is an invasive modality which provides cross-sectional images of a coronary artery. In these images both the lumen and outer vessel wall can be identified and accurate estimations of their dimensions and of the plaque burden can be obtained. In addition, further processing of the IVUS backscatter signal helps in the(More)
Intravascular ultrasound (IVUS) virtual histology (VH-IVUS) is a new technique, which provides automated plaque characterization in IVUS frames, using the ultrasound backscattered RF-signals. However, its computation can only be performed once per cardiac cycle (ECG-gated technique), which significantly decreases the number of characterized IVUS frames.(More)