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MAPK signal transduction pathways are important regulators of stress responses, cellular growth, and differentiation. In Neurospora, the circadian clock controls rhythms in phosphorylation of the p38-like MAPK (OS-2); however, the mechanism for this regulation is not known. We show that the WCC, a transcription factor and clock component, binds to the os-4(More)
The OS-pathway mitogen-activated protein kinase (MAPK) cascade of Neurospora crassa is responsible for adaptation to osmotic stress. Activation of the MAPK, OS-2, leads to the transcriptional induction of many genes involved in the osmotic stress response. We previously demonstrated that there is a circadian rhythm in the phosphorylation of OS-2 under(More)
Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have(More)
Reina S. Mayor, Katelyn E. Finch, Jordan Zehr, Eugenia Morselli, Michael D. Neinast, Aaron P. Frank, Lisa D. Hahner, Jason Wang, Dinesh Rakheja, Biff F. Palmer, Charles R. Rosenfeld, Rashmin C. Savani, and Deborah J. Clegg Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas(More)
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