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We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3 ligase that ubiquitinates Bim in this model, using a proteomics approach. Using phosphorylated GST-Bim as(More)
BACKGROUND Granulocyte colony-stimulating factor (G-CSF) is a pro-inflammatory cytokine that stimulates myeloid stem cell maturation, proliferation, and migration into circulation. Despite being a known growth factor, the impact of G-CSF on solid tumours has not been well examined. G-CSF receptor (G-CSFR) is expressed by some tumours, and thus the aim of(More)
The aim of the study was to assess dimensions of the patient-clinician relationship in relation to adherence with antiretroviral medication in a sample of HIV patients. This was a correlational evaluation, using a cross-sectional design. Thirty-eight HIV patients in two UK HIV units provided complete data. Analysis suggested that the elements of the(More)
Heap ordered trees are planted plane trees, labelled in such a way that the labels always increase from the root to a leaf. We study two parameters, assuming that p of the n nodes are selected at random: the size of the ancestor tree of these nodes and the smallest subtree generated by these nodes. We compute expectation, variance, and also the Gaussian(More)
(2015) Exploring inequities in child welfare and child protection services: explaining the 'inverse intervention law', Children and Youth Services Review, 57, pp. 98-105. ABSTRACT Attempts to record, understand and respond to variations in child welfare and protection reporting, service patterns and outcomes are international, numerous and longstanding.(More)
Abstract Long-term storage of banked sperm, especially when it is not needed, for reproductive purposes, is costly and poses practical problems for sperm banks. For sperm banks to function efficiently, men must understand the implications of unnecessary storage, and make timely decisions about disposal of their own samples. Men who bank sperm prior to(More)
Current policy in the UK recommends that men bank sperm prior to cancer treatment, but very few return to use it for reproductive purposes or agree to elective disposal even when their fertility recovers and their families are complete. We assessed the demographic, medical and psychological variables that influence the decision to dispose by contacting men(More)
2015. Exploring inequities in child welfare and child protection services: Explaining the 'inverse intervention law'. Please note: Changes made as a result of publishing processes such as copy-editing, formatting and page numbers may not be reflected in this version. For the definitive version of this publication, please refer to the published source. You(More)
Peace, both personal and global, resides in understanding. Verbatim theatre is introduced as a vehicle for translating research findings to promote understanding and thereby, promote health. By shifting our translation lens from "bench to bedside" to "field to forum," new opportunities arise for moving nursing research-findings to an engaged audience.(More)
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