Kate L. Cueno

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Singlet oxygen initiates lipid peroxidation via a nonfree radical mechanism by reacting directly with unsaturated lipids to form lipid hydroperoxides (LOOHs). These LOOHs can initiate free radical chain reactions leading to membrane leakage and cell death. Here we compare the ability and mechanism by which three small-molecule membrane antioxidants(More)
L-H represents a lipid, generally a polyunsaturated fatty acid moiety (PUFA). (See Figure 1 legend for an explanation of the abbreviations used to denote the various chemical species associated with lipid peroxidation). The rate of the propagation event is governed by the various carbon-hydrogen bond dissociation energies along the lipid chain (Cosgrove et(More)
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