Kate E. Dawson

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UNLABELLED There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE). OBJECTIVES We aimed to validate an improved revision (the ACE-R) which incorporates five sub-domain scores (orientation/attention, memory, verbal fluency, language and(More)
OBJECTIVE To evaluate a cognitive test, the TYM ("test your memory"), in the detection of Alzheimer's disease. DESIGN Cross sectional study. SETTING Outpatient departments in three hospitals, including a memory clinic. PARTICIPANTS 540 control participants aged 18-95 and 139 patients attending a memory clinic with dementia/amnestic mild cognitive(More)
A great deal has been written about cognitive aspects of semantic dementia but little is known about the demography or prognosis. We describe these features in a consecutive series of 100 patients seen over a 17-year period; all cases were assessed and followed up in a specialist clinic. The mean age at diagnosis was 64.2 (+/-7.1) range 40-79 years, but 46(More)
This study investigated cross-sectional and longitudinal neuropsychological data from 55 patients: 38 with Alzheimer's disease and 18 with mild cognitive impairment (MCI). The analyses were designed to investigate two issues: the relationship of MCI to Alzheimer's disease, and that of atypical to typical Alzheimer's disease. When longitudinal data were(More)
Although it is well recognized that MCI represents a risk state for subsequent dementia, estimates of conversion vary widely according to the diagnostic criteria employed. There are currently no simple cognitive predictors of high and low risk of progression. We followed 107 non-demented non-depressed subjects from an original cohort of 124—sub-classified(More)
BACKGROUND/AIMS We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). METHOD The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary(More)
OBJECTIVE The aim of this study is the evaluation of a novel cognitive test, the hard Test Your Memory (H-TYM), in the detection of mild Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). METHODS This paper uses a prospective study in an outpatient memory clinic. We recruited 97 patients with a diagnosis of mild AD or aMCI aged(More)
OBJECTIVES To estimate the lifetime risk, prevalence, incidence, and mortality of the principal clinical syndromes associated with frontotemporal lobar degeneration (FTLD) using revised diagnostic criteria and including intermediate clinical phenotypes. METHODS Multisource referral over 2 years to identify all diagnosed or suspected cases of(More)
BACKGROUND The Addenbrooke's Cognitive Examination (ACE) is a simple diagnostic tool bridging the gap between the very brief Mini Mental State Exam (MMSE) and much longer test batteries used by neuropsychologists which has proven extremely popular internationally. OBJECTIVE We aimed to assess the ability of the ACE to differentiate semantic dementia (SD)(More)
Complaints related to memory are characteristic of normal ageing, affective disorders, and are a cardinal feature of amnestic mild cognitive impairment (aMCI), the proposed prodrome to Alzheimer disease proper. The aim of this study was to investigate the profile of subjective memory complaints in different cognitive syndromes. Subjective memory was(More)