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- K D Costa, Y Takayama, A D McCulloch, J W Covell
- The American journal of physiology
- 1999

Previous studies suggest that the laminar architecture of left ventricular myocardium may be critical for normal ventricular mechanics. However, systolic three-dimensional deformation of the laminae has never been measured. Therefore, end-systolic finite strains relative to end diastole, from biplane radiography of transmural markers near the apex and base… (More)

Indentation using the atomic force microscope (AFM) has potential to measure detailed micromechanical properties of soft biological samples. However, interpretation of the results is complicated by the tapered shape of the AFM probe tip, and its small size relative to the depth of indentation. Finite element models (FEMs) were used to examine effects of… (More)

- J M Guccione, K D Costa, A D McCulloch
- Journal of biomechanics
- 1995

A three-dimensional finite element model was used to explore whether or not transmural distributions of end-diastolic and end-systolic fiber stress are uniform from the apex to the base of the canine left ventricular wall. An elastance model for active fiber stress was incorporated in an axisymmetric model that accurately represented the geometry and fiber… (More)

- T Arts, K D Costa, J W Covell, A D McCulloch
- American journal of physiology. Heart and…
- 2001

Cardiac myofibers are organized into laminar sheets about four cells thick. Recently, it has been suggested that these layers coincide with the plane of maximum shear during systole. In general, there are two such planes, which are oriented at +/-45 degrees to the main principal strain axes. These planes do not necessarily contain the fiber axis. In the… (More)

- K D Costa, P J Hunter, J S Wayne, L K Waldman, J M Guccione, A D McCulloch
- Journal of biomechanical engineering
- 1996

A three-dimensional finite element method for nonlinear finite elasticity is presented using prolate spheroidal coordinates. For a thick-walled ellipsoidal model of passive anisotropic left ventricle, a high-order (cubic Hermite) mesh with 3 elements gave accurate continuous stresses and strains, with a 69 percent savings in degrees of freedom (dof) versus… (More)

- J M Guccione, S M Moonly, +4 authors M K Pasque
- The Annals of thoracic surgery
- 2001

BACKGROUND
The global left ventricular dysfunction characteristic of left ventricular aneurysm is associated with muscle fiber stretching in the adjacent noninfarcted (border zone) region during isovolumic systole. The mechanism of this regional dysfunction is poorly understood.
METHODS
An anteroapical transmural myocardial infarct was created by coronary… (More)

- K D Costa, K May-Newman, D Farr, W G O'Dell, A D McCulloch, J H Omens
- The American journal of physiology
- 1997

All previous studies of residual strain in the ventricular wall have been based on one- or two-dimensional measurements. Transmural distributions of three-dimensional (3-D) residual strains were measured by biplane radiography of columns of lead beads implanted in the midanterior free wall of the canine left ventricle (LV). 3-D bead coordinates were… (More)

- G A Ateshian, K D Costa, C T Hung
- Biomechanics and modeling in mechanobiology
- 2007

Because of the avascular nature of adult cartilage, nutrients and waste products are transported to and from the chondrocytes by diffusion and convection through the extracellular matrix. The convective interstitial fluid flow within and around chondrocytes is poorly understood. This theoretical study demonstrates that the incorporation of a semi-permeable… (More)

- R Krishnan, M Caligaris, R L Mauck, C T Hung, K D Costa, G A Ateshian
- Osteoarthritis and cartilage
- 2004

OBJECTIVE
To investigate the role of the superficial zone in regulating the frictional response of articular cartilage. This zone contains the superficial protein (SZP), a proteoglycan synthesized exclusively by superficial zone chondrocytes and implicated in reducing the friction coefficient of cartilage.
DESIGN
Unconfined compression creep tests with… (More)

- K D Costa, P J Hunter, J M Rogers, J M Guccione, L K Waldman, A D McCulloch
- Journal of biomechanical engineering
- 1996

A three-dimensional Galerkin finite element method was developed for large deformations of ventricular myocardium and other incompressible, nonlinear elastic, anisotropic materials. Cylindrical and spherical elements were used to solve axisymmetric problems with r.m.s. errors typically less than 2 percent. Isochoric interpolation and pressure boundary… (More)