Learn More
Low density lipoprotein (LDL) and beta-very low density lipoprotein (beta-VLDL) are internalized by the same receptor in mouse peritoneal macrophages and yet their endocytic patterns differ; beta-VLDL is targeted to both widely distributed and perinuclear vesicles, whereas LDL is targeted almost entirely to perinuclear lysosomes. This endocytic divergence(More)
Syntax sets human language apart from other natural communication systems, although its evolutionary origins are obscure. Here we show that free-ranging putty-nosed monkeys combine two vocalizations into different call sequences that are linked to specific external events, such as the presence of a predator and the imminent movement of the group. Our(More)
indeed he played the major role in its development. But the idea originated with Price, in an unpublished manuscript that Maynard Smith had reviewed for Nature. Maynard Smith later explained that " Dr Price is better at having ideas than at publishing them. The best I can do therefore is to acknowledge that if there is anything in the idea the credit should(More)
Many animal vocal signals are given in a wide range of contexts which can sometimes have little in common. Yet, to respond adaptively, listeners must find ways to identify the cause of a signal, or at least rule out alternatives. Here, we investigate the nature of this process in putty-nosed monkeys, a forest primate. In this species, adult males have a(More)
This study investigated the relationship between spectral noise level (SNL) and perceived roughness in sustained vowels phonated by children. Twenty male children, ten presenting normal vocal quality and ten presenting vocal roughness associated with benign vocal cord lesions, served as subjects. The children individually sustained each of the vowels(More)
Syntax is widely considered the feature that most decisively sets human language apart from other natural communication systems. Animal vocalisations are generally considered to be holistic with few examples of utterances meaning something other than the sum of their parts. Previously, we have shown that male putty-nosed monkeys produce call series(More)
Beta very low density lipoproteins (beta-VLDL) from cholesterol-fed animals from patients with Type III hyperlipoproteinemia are internalized by a receptor-mediated process in mouse macrophages. Once internalized, the cholesteryl esters of beta-VLDL are hydrolyzed in lysosomes, and the released cholesterol is re-esterified, resulting in a massive(More)
Both apolipoprotein (apo) E2 and apoE-Leiden (tandem repeat of amino acids 121-127) are associated with type III hyperlipoproteinemia and bind defectively to low density lipoprotein receptors. Removing the carboxyl terminus of both variants (residues 192-299) increases receptor-binding activity, suggesting that the carboxyl terminus modulates activity. To(More)
Evaluating the NHS Direct Online website presents some challenges and therefore a number of evaluation methods and approaches are utilized by NHS Direct. This paper presents one approach, web log analysis, to explore how users interact with the NHS Direct Online website. Focusing on one health topic, MRSA for one-day's website visits, proved informative and(More)