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Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/β-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/β-catenin pathway, we(More)
Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1ϵ (CK1ϵ) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylation. Currently it is not clear which Dvl residues are(More)
The effect of 5-oxytryptophan, injected singly and in combination with the serotonin antagonists (novocain, atropine and bigumal) on the ascorbic acid level in the adrenal cortex and the eosinophilic content in the peripheral blood of white rats was studied. It was ascertained that 5-oxytryptophan reduced significantly the amount of ascorbic acid in the(More)
In experiments with rabbits is shown weak toxic action of managanese chloride (0,5 and 5 mg/kg intravenously for 2 months) on the organism of animals. The blood managanese level rose only when the element was introduced in a large dose. The ascorbic acid content in the supprarenals diminished. At the site of the preparation administration (muscles) were in(More)
Dishevelled (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways. Here, we present conclusive evidence that DVL regulates the centrosomal cycle. We demonstrate that DVL dishevelled and axin (DIX) domain, but not DIX domain-mediated multimerization, is essential for DVL's centrosomal localization. DVL accumulates during the cell(More)