Katayoo Shirneshan

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LMO1 is a transcriptional regulator and a T-acute lymphoblastic leukaemia (T-ALL) oncogene. Although first identified in association with a chromosomal translocation in T-ALL, the ectopic expression of LMO1 occurs far more frequently in the absence of any known mutation involving its locus. Given that LMO1 is barely expressed in any haematopoietic lineage,(More)
Herein we report on an open-label, nonrandomized, single-arm, multicenter-, phase II trial conducted by the German MDS-StudyGroup, evaluating the safety of lenalidomide in myelodysplastic syndrome (MDS) with isolated del(5q) and trying to identify patterns of disease progression (LE-MON5; EudraCT number: 2008‐001866‐10). The primary endpoint was safety,(More)
Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 2001; 25: 529–536. 12 Escribano L, Orfao A, Diaz-Agustin B, Villarrubia J, Cervero C, Lopez A et al. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells(More)
1 O'Hare T, Zabriskie MS, Eiring AM, Deininger MW. Pushing the limits of targeted therapy in chronic myeloid leukaemia. Nat Rev Cancer 2012; 12: 513–526. 2 Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL. BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the(More)
We report on the characterization of a de novo, apparently balanced translocation t(X;15)(p11.3;q26) detected in a girl with multiple congenital malformations. Replication banding studies on Epstein-Barr virus transformed peripheral blood lymphocytes revealed non-random X chromosome inactivation with predominant inactivation of the derivative X chromosome.(More)
A 62-yr-old man with two healthy daughters was diagnosed with osteomyelofibrosis. To our surprise, a female XX-karyotype was observed in bone marrow and confirmed in PHA-stimulated T-lymphocytes from peripheral blood. Further molecular genetic investigation revealed a submicroscopic translocation between the short arm of X and Y, which leads to an XX-male(More)
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