Katarzyna M Bloch
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Pharmacogenetics of antiepileptic drug-induced hypersensitivity.
- Katarzyna M Bloch, G. Sills, M. Pirmohamed, A. Alfirevic
- Biology, Medicine
- 4 June 2014
Antiepileptic drugs can induce potentially life-threatening hypersensitivity reactions such as Stevens-Johnson syndrome at a frequency of one in 10,000 to one in 1000 treated patients. There is a… Expand
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study
- D. Hawcutt, B. Francis, +16 authors M. Pirmohamed
- The Lancet. Respiratory medicine
- 1 June 2018
Summary Background A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal… Expand
Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
Aims Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous… Expand
Whole exome sequencing in individuals with statin-induced myopathy
Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and ARB induced angioedema.
- C. Maroteau, Moneeza Kalhan Siddiqui, +19 authors C. Palmer
- Clinical pharmacology and therapeutics
- 4 June 2020
Angioedema occurring in the head and neck region is a rare and sometimes life-threatening adverse reaction to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB).… Expand