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Pharmacogenetics of antiepileptic drug-induced hypersensitivity.
Antiepileptic drugs can induce potentially life-threatening hypersensitivity reactions such as Stevens-Johnson syndrome at a frequency of one in 10,000 to one in 1000 treated patients. There is aExpand
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Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study
Summary Background A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenalExpand
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  • Open Access
Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
Aims Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. PreviousExpand
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  • Open Access
Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and ARB induced angioedema.
Angioedema occurring in the head and neck region is a rare and sometimes life-threatening adverse reaction to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB).Expand