Katarzyna Czarnobaj

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The aim of this study was to estimate the concentration of total selenium in serum women with thyroid gland disease. Selenium was determined by atomic absorption spectrometry using the hydride generation technique (HG-AAS). Selenium was determined in 30 patients with thyroid gland disease and in 12 healthy controls. Selenium concentration of serum was(More)
The aim of the present study was to utilize the sol-gel method to synthesize different forms of xerogel matrices for drugs and to investigate how the synthesis conditions and solubility of drugs influence the change of the profile of drug release and the structure of the matrices. Silica xerogels doped with drugs were prepared by the sol-gel method from a(More)
SiO2, SiO2/PEG and SiO2/PDMS xerogels were examined as polymeric carriers for the controlled release of cisplatin--an antineoplasmic medicine. Drug/carrier systems were prepared by the sol-gel method. The effect of organic substitution of the silica xerogel matrix and drying conditions on the release of cisplatin was evaluated. Based on the presented(More)
Silica, silica/polydimethylsiloxane and silica/polydimethylsiloxane/ calcium xerogels were examined as polymeric carriers for the controlled release of drug—Metronidazole. Characterization assays comprised analysis of the matrix by Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET) and scanning electron(More)
Silica xerogels doped with diclofenac diethylamine were prepared by the sol-gel method from a hydrolysed tetraethoxysilane (TEOS) solution containing diclofenac diethylamine. Two different catalysts, drying conditions and levels of water content were used to alter the microstructure of the silica xerogels. The aim of this study was to determine the rate of(More)
The aim of this study was to evaluate the physical properties, chemical structure and bioactivity of sol-gel processed oxide (SiO(2)-CaO-P(2)O(5)) composites used as controlled release materials for Metronidazole-drug applied in periodontal disease treatment. The obtained composite materials were characterized by Fourier transform infrared spectroscopy(More)
The aim of this study was to obtain stable and controlled release silica xerogels containing metronidazole (MT) prepared with surfactants with different charges: cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulphate (SDS) and hydroxypropyl cellulose (HPC), which could be the promising carrier materials used as the implantable drug delivery systems.(More)
In this study, oxide and polymer/oxide xerogels with metronidazole were prepared and examined as carriers of drug for the local application to the bone. The nanoporous SiO2–CaO–P2O5 and HPC–SiO2–CaO–P2O5 xerogel materials with different amounts of the polymer [hydroxypropyl cellulose (HPC)] were prepared using the sol–gel technology, and their(More)
The aim of this study was to evaluate the surface mineralization activity and in vitro drug behaviour potential of new mesoporous silica microparticles (MSM). The unmodified MSM (MSM-0%Ca) and calcium-modified MSM (MSM-5%Ca, MSM-15%Ca, MSM-25%Ca) were prepared using the self-assembling method. Calcium diethoxide was used as a calcium precursor. Doxorubicin(More)
Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation--by the predoping method--and already upon receipt of hard xerogel--the postdoping method. Further, the research aimed at the determination of the(More)