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A shared feature of many neural circuits is their organization into synaptic layers. However, the mechanisms that direct neurites to distinct layers remain poorly understood. We identified a central role for Netrins and their receptor Frazzled in mediating layer-specific axon targeting in the Drosophila visual system. Frazzled is expressed and cell(More)
The ability of vertebrates and insects to perceive and process information about the visual world is mediated by neural circuits, which share a strikingly conserved architecture of reiterated columnar and layered synaptic units. Recent genetic approaches conferring single-cell resolution have enabled major advances in our understanding of the cellular and(More)
During the development of locomotion circuits it is essential that motoneurons with distinct subtype identities select the correct trajectories and target muscles. In vertebrates, the generation of motoneurons and myelinating glia depends on Olig2, one of the five Olig family bHLH transcription factors. We investigated the so far unknown function of the(More)
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