Learn More
The persistent presence of polymorphonuclear neutrophils (PMN) in airways is the hallmark of cystic fibrosis (CF) disease. The aim of this study was to assess the PMN adherence, the percentage of apoptotic airway PMN and production of cytokines IL-6 and IL-8 when airway PMN are in contact with airway epithelial cells. Before the co-culture, freshly isolated(More)
BACKGROUND Development of T-cells based-Interferon gamma (IFNgamma) assays has offered new possibilities for the diagnosis of latent tuberculosis infection (LTBI) and active disease in adults. Few studies have been performed in children, none in France. With reference to the published data on childhood TB epidemiology in the Paris and Ile de France Region,(More)
BACKGROUND The variability in the inflammatory burden of the lung in cystic fibrosis (CF) patients together with the variable effect of glucocorticoid treatment led us to hypothesize that glucocorticoid receptor (GR) gene polymorphisms may affect glucocorticoid sensitivity in CF and, consequently, may contribute to variations in the inflammatory response.(More)
  • 1