Katalin M. Hangos

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This paper presents new results about the optimization based generation of chemical reaction networks (CRNs) of higher deficiency. Firstly, it is shown that the graph structure of the realization containing the maximal number of reactions is unique if the set of possible complexes is fixed. Secondly, a mixed integer programming based numerical procedure is(More)
In this paper a simple one compartment Hodgkin-Huxley type electrophysiological model of GnRH neurons is presented, that is able to reasonably reproduce the most important qualitative features of the firing pattern, such as baseline potential, depolarization amplitudes, sub-baseline hyperpolarization phenomenon and average firing frequency in response to(More)
A multiagent diagnostic system implemented in a Protégé-JADE-JESS environment interfaced with a dynamic simulator and database services is described in this paper. The proposed system architecture enables the use of a combination of diagnostic methods from heterogeneous knowledge sources. The process ontology and the process agents are designed based on the(More)
In this letter we show that closed reversible chemical reaction networks with independent elementary reactions admit a global pseudo-Hamiltonian structure which is at least locally dissipative around any equilibrium point. The structure matrix of the Hamiltonian description reflects the graph topology of the reaction network and it is a smooth function of(More)
Reversibility, weak reversibility and deficiency, detailed and complex balancing are generally not "encoded" in the kinetic differential equations but they are realization properties that may imply local or even global asymptotic stability of the underlying reaction kinetic system when further conditions are also fulfilled. In this paper, efficient(More)
A prototype prediction based intelligent diagnostic system that is capable of integrating qualitative and quantitative process models and operation experience in the form of HAZOP result tables is proposed in this paper. The knowledge base of the system is organized in a hierarchical way following the hierarchy levels of the multi-scale model of the process(More)
An ontology for representing operating, safety and control procedures is proposed in this paper that supports diagnosis based on following these procedures and combining observed malfunctions with Failure Mode and Effects Analysis (FMEA) information. The procedure ontology is defined within interconnected components of the process plant, diagnostic analysis(More)