Kaspar Schüpbach

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BACKGROUND Type III secretion systems (TTSS) are employed by numerous pathogenic and symbiotic bacteria to inject a cocktail of different "effector proteins" into host cells. These effectors subvert host cell signaling to establish symbiosis or disease. METHODOLOGY/PRINCIPAL FINDINGS We have studied the injection of SipA and SptP, two effector proteins of(More)
Many railway companies in Europe operate periodic timetables. Yet, most timetables are not entirely periodic but have a mixture of different periodicity and many exceptions to cope with changing demand. Current approaches for automatic timetable generation are not able to deal with such partially periodic structure, but consider only fully periodic inputs.(More)
Abstract. This paper addresses the problem of generating conflict-free periodic train timetables for large railway networks. We follow a two level approach, where a simplified track topology is used to obtain a macro-level schedule, and the detailed topology is considered locally on the micro level. To increase the solution space in the interface of the two(More)
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