Kaspar Schüpbach

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BACKGROUND Type III secretion systems (TTSS) are employed by numerous pathogenic and symbiotic bacteria to inject a cocktail of different "effector proteins" into host cells. These effectors subvert host cell signaling to establish symbiosis or disease. METHODOLOGY/PRINCIPAL FINDINGS We have studied the injection of SipA and SptP, two effector proteins of(More)
This paper addresses the problem of generating conflict-free periodic train timetables for large railway networks. We follow a two level approach, where a simplified track topology is used to obtain a macro-level schedule, and the detailed topology is considered locally on the micro level. To increase the solution space in the interface of the two levels,(More)
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