Kaspar Friedrich

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The 2',3'-dideoxy analogue of the potent A1 receptor agonist, N6-cyclohexyladenosine (CHA), was synthesized as a potential antagonist for the A1 adenosine receptor. In studies on adenylate cyclase 2',3'-dideoxy-N6-cyclohexyladenosine (ddCHA) did not show agonist properties at A1 or at A2 receptors. However, it antagonized the inhibition by R-PIA of(More)
The 5-hydroxytryptamine receptor of type 3 was investigated by fluorescence correlation spectroscopy (FCS). Binding constants of fluorescently labeled ligands, the stoichiometry, and the mass of the receptor are readily accessible by this technique, while the duration of measurement is on the order of seconds to minutes. The receptor antagonist 1,2,3,(More)
Authors summarize the results of liver transplantation first of all in the view of rehabilitation. Role of rehabilitation experts is discussed in the period before and after transplantation. The necessity of information for the patients is specially underlined already from the first raise of the possibility of liver transplantation. They express that after(More)
Liver iron and copper concentrations were estimated in 395 patients undergoing hepatological examination. Relations to clinical, morphological and laboratory data were evaluated. Liver iron concentrations were not significantly different in chronic hepatitis of viral, toxic or immunological origin. Liver iron levels exceeding 100 mg/100 g dry liver tissue(More)
We investigated the question as to whether benign cholangiofibromas of the liver (biliary microharmatomas) show specific structures in ultrasound. Patients with single, sporadic, multiple or diffuse cholangiofibromas (n = 53), detected by laparoscopy and verified by histology, were examined by ultrasound. The single and sporadic type (n = 30) could not be(More)
Within the framework of a prospective study, we were able to establish that in 50 per cent of 220 patients submitted to laparoscopy, the ligamentum teres hepatis did not run from the porta hepatis directly to the umbilicus, but to a point of insertion craniad to the umbilicus in the median line of the anterior abdominal wall. As a rule, this topographic(More)
From 1976 to 1982 in 279 patients amongst 3719 laparoscopies focal fatty liver infiltrates were found at the right and/or left liver edge next to the insertion point of the round ligament. These so-called "yellow spots" mainly could be recognized in case of normal liver tissue and in cases suffering from chronic hepatitis insofar as a cirrhotic(More)
In a current series of 1160 laparoscopies in 38 cases (3.2%) we found cholangiofibromas. The picture of single, sporadic and multiple cholangiofibromas as well as cholangiofibromatosis is both described and documented by laparoscopic photography. Clinically it seems remarkable that only patients with alcohol- or drug-induced liver injury showed such(More)
We report on a case of a 45 years old man suffering from ulcerative colitis accompanied by a protein-loosing-syndrome (hypoalbuminaemia). The significant decrease of cholinesterase (CHE) and quick level, edemas of the legs and forearms, pleural effusion and ascites had been misinterpreted as signs of liver insufficiency. Low protein diet was given and,(More)