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Current text based Software Configuration Management (SCM) systems have trouble with refactorings. Refactorings result in global changes which lead to merge conflicts. A refactoring-aware SCM system reduces merge conflicts. This paper describes MolhadoRef, a refactoring-aware SCM system and the merge algorithm at its core. MolhadoRef records change(More)
Current text based Software Configuration Management (SCM) systems have trouble with refactorings. Refactorings result in global changes and lead to merge conflicts. A refactoring-aware SCM system reduces merge conflicts, preserves program history better and makes it easier to understand program evolution. This paper describes MolhadoRef, a(More)
Refactoring tools allow programmers to change their source code quicker than before. However, the complexity of these changes cause versioning tools that operate at a file level to lose the history of entities and be unable to merge refactored entities. This problem can be solved by semantic, operation-based SCM with persistent IDs. We propose that(More)
According to the US Food and Drug Administration (FDA), if a drug product contains a drug substance that is chemically identical and is delivered to the site of action at the same rate and extent as another drug product, then it is equivalent and can be substituted (switchable) for that drug product. Methods used to define bioequivalence as stated by the(More)
We studied the pharmacokinetics (PKs) of the new generic cyclosporine formulation, Equoral capsules, after the switch from original formulation Neoral capsules in stable renal transplant patients. The study was carried out in accordance with the basic principles defined in the US 21 CFR Part 312.20 and the principles of the Declaration of Helsinki. The(More)
Disseminated cryptococcosis mainly occurs in patients with impaired cell mediated immunity. We present a case of disseminated cryptococcosis in a non-HIV patient with nephrotic syndrome who never received immunosuppression. Cultures of bone marrow aspirate, cerebrospinal fluid analysis and histology of skin lesions were all consistent with Cryptococcus(More)
Crescentic glomerulonephritis complicating the course of bacterial endocarditis carries a poor prognosis. Ideal treatment strategy is not clearly defined. In addition to antibiotic treatment, plasmapheresis and steroids have been used with variable results. Here we report a case of 40-year old female who was referred because of generalized body swelling and(More)
The course of pregnancy and its outcome was studied in renal allograft recipients. Between November 1985 and November 2005, a total of 1481 renal transplants were carried out at the Sindh Institute of Urology and Transplantation (SIUT); among them were 348 females, with 73 potential females for pregnancy. All patients received cyclosporine and prednisolone,(More)
Refactoring tools allow programmers to change source code much quicker than before. However, the complexity of these changes cause versioning tools that operate at a file level to lose the history of components. This problem can be solved by semantic, operation-based SCM with persistent IDs. We propose that versioning tools be aware of the program entities(More)