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BACKGROUND Erythrocytic pyruvate kinase (PK) deficiency, first documented in Basenjis, is the most common inherited erythroenzymopathy in dogs. OBJECTIVES To report 3 new breed-specific PK-LR gene mutations and a retrospective survey of PK mutations in as mall and selected group of Beagles and West Highland White Terriers (WHWT). ANIMALS Labrador(More)
BACKGROUND Cystinuria, one of the first recognized inborn errors of metabolism, has been reported in many dog breeds. HYPOTHESIS/OBJECTIVES To determine urinary cystine concentrations, inheritance, and mutations in the SLC3A1 and SLC7A9 genes associated with cystinuria in 3 breeds. ANIMALS Mixed and purebred Labrador Retrievers (n = 6), Australian(More)
BACKGROUND Cystinuria is an inherited metabolic disease that is relatively common in dogs, but rare in cats and is characterized by defective amino acid reabsorption, leading to cystine urolithiasis. OBJECTIVES The aim of this study was to report on a mutation in a cystinuric cat. ANIMALS A male domestic shorthair (DSH) cat with cystine calculi, 11(More)
BACKGROUND Based upon serology, >10 canine blood group systems have been reported. OBJECTIVE We surveyed dogs for dog erythrocyte antigen (DEA) 1 and 2 new blood types (Kai 1 and Kai 2), and some samples also were screened for Dal and DEA 3, 4, and 7. METHODS Blood samples provided by owners, breeders, animal blood banks, and clinical laboratories were(More)
Introduction Disorders of the renal proximal tubules can cause selective or generalized aminoaciduria and may be associated with urinary losses of other solutes such as glucose, lactate, electrolytes and bicarbonate. Two renal tubular defects involving amino acids have long been recognized in dogs, namely cystinuria, leading to cystine calculi and urinary(More)
BACKGROUND The Dog erythrocyte antigen (DEA) 1 blood group system was thought to contain types DEA 1.1 and 1.2 (and possibly 1.3 [A3]). However, DEA 1.2+ dogs are very rare and newer typing methods reveal varying degrees of DEA 1 positivity. OBJECTIVES To assess if variation in DEA 1 positivity is because of quantitative differences in surface antigen(More)
BACKGROUND The dog erythrocyte antigen (DEA) 1 blood group system remains poorly defined. OBJECTIVES The purpose of the study was to determine the DEA 1 mode of inheritance and to characterize the DEA 1 antigen and alloantibodies. ANIMALS Canine research colony families, clinic canine patients, and DEA 1.2+ blood bank dogs were studied. METHODS Canine(More)
BACKGROUND Difficulties with the direct antiglobulin test (DAT) and its apparent lack of sensitivity and specificity for immune-mediated hemolytic anemia (IMHA) in dogs have raised skepticism regarding its diagnostic value. OBJECTIVE To compare different DATs and other hematologic parameters in dogs. ANIMALS Anticoagulated blood samples from 59(More)
AIM To investigate and characterise an inborn error of metabolism in a dog with skeletal and ocular abnormalities. METHODS A 2.5-year-old small male Miniature Poodle-like dog was presented with gross joint laxity and bilateral corneal opacities. Clinical examination was augmented by routine haematology, serum chemistry, radiographs, pathology, enzymology(More)
BACKGROUND Finding compatible feline blood donors can be challenging. Canine blood has been occasionally used when compatible feline blood was not available in emergency situations. OBJECTIVES The study goals were to describe the effects of xenotransfusion in 2 anemic cats receiving canine blood because of discordant blood types and acute transfusion(More)