Karthik K. Srinivasan

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The antitumor and radiosensitizing effects of withaferin A (WA), a steroidal lactone from Withania somnifera, was studied on Ehrlich ascites carcinoma in vivo. The acute LD50(14) for WA in Swiss mice was approximately 80 mg/kg. Twenty-four hours after i.p. inoculation of 10(6) tumor cells, WA was injected i.p. at different dose fractions (5 or 7.5 mg/kg x(More)
Ethanol extract (FRE) and water extract (FRW) of Ficus racemosa (family: Moraceae) were subjected to free radical scavenging both by steady state and time resolved methods such as nanosecond pulse radiolysis and stopped-flow spectrophotometric analyses. FRE exhibited significantly higher steady state antioxidant activity than FRW. FRE exhibited(More)
Advanced Traveler Information Systems (ATIS), by providing real-time traffic information, can assist trip-makers in selecting efficient travel choices, and aid the attainment of desirable system goals including reduced costs and increased efficiencies. The success of ATIS in achieving such goals critically depends on user behavior in response to(More)
In this paper, a joint hazard-based model is proposed to analyze simultaneous (mutually interdependent) duration processes. The proposed model generalizes independent hazard based models by accounting for correlations between simultaneous duration processes. Further, the model also permits flexible and variable hazard function parameters to capture(More)
This paper investigates day-to-day dynamics in urban traffic network induced by departure time dynamics in commuter decisions. This investigation relaxes some key restrictions regarding fixed departure time and equilibrium assumptions to analyze the stability and performance of urban traffic networks over a multiple day planning horizon. A simulation-based(More)
Recent research has yielded evidence that freeway capacity expansions may generate, or induce, demand for travel that did not exist prior to the expansion. The phenomenon of induced demand has important implications for congestion and air quality. This paper presents a threepronged approach to understanding the impacts of capacity expansions on development(More)
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