Karthik Gopalakrishnan

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High-performance systems are undergoing a major shift as commodity multi-core systems become increasingly prevalent. As the number of processes per compute node increase, the other parts of the system must also scale appropriately to maintain a balanced system. In the area of high-performance computing, one very important element of the overall system is(More)
Batch foam separation has been employed to separate Saccharomyces carlsbergensis cells from their broth without the use of any external surface-active agent. A model has been developed to predict the foamate cell concentration as well as the variation of cell concentration in the bulk liquid in the foam column as a function of time. The model assumes a(More)
Large scale compute clusters continue to grow to ever-increasing proportions. However, as clusters and applications continue to grow, the Mean Time Between Failures (MTBF) has reduced from days to hours. As a result, fault tolerance within the cluster has become imperative. MPI, the de-facto standard for parallel programming, is widely used on such large(More)
Clusters and applications continue to grow in size while their mean time between failure (MTBF) is getting smaller. Checkpoint/Restart is becoming increasingly important for large scale parallel jobs. However, the performance of the Checkpoint/Restart mechanism does not scale well with increasing job size due to constraints within the file system.(More)
Biomass and lipid accumulation of heterotrophic microalgae Chlorella protothecoides by supplying mixed waste substrate of brewer fermentation and crude glycerol were investigated. The biomass concentrations of the old and the new C. protothecoides strains on day 6 reached 14.07 and 12.73 g/L, respectively, which were comparable to those in basal medium with(More)
— The air transportation system is a network of many interacting, capacity-constrained elements. When the demand for airport and airspace resources exceed the available capacities of these resources, delays occur. The state of the air transportation system at any time can be represented as a weighted directed graph in which the nodes correspond to airports,(More)
Adult hippocampal neurogenesis can be modulated by various physiological and pathological conditions, including stress, affective disorders, and several neurological conditions. Given the proposed role of this form of structural plasticity in the functioning of the hippocampus (namely learning and memory and affective behaviors), it is believed that(More)
The development of synthetic small molecules capable of promoting neuronal fate in stem cells is a promising strategy to prevent the decline of hippocampal function caused by several neurological disorders. Within this context, isoxazole 9 (Isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (SGZ)(More)