Karthik Balakrishnan

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The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response(More)
This paper examines and compares several di erent approaches to the design of intelligent systems for diagnosis applications. These include expert systems (or knowledgebased systems), truth (or reason) maintenance systems, case-based reasoning systems, and inductive approaches like decision trees, arti cial neural networks (or connectionist systems), and(More)
The impact of contacts on device and circuit performance is becoming larger with technology scaling because of higher resistance as well as increased variability. Thus, techniques are needed for measurement, analysis, and modeling of variation in contactss, and for devices, interconnects, and circuits in general, in order to ensure robust circuit design. A(More)
In this paper, we propose a new technique to achieve accurate decomposition of process variation by efficiently performing spatial pattern analysis. We demonstrate that the spatially correlated systematic variation can be accurately represented by the linear combination of a small number of templates. Based on this observation, an efficient sparse(More)
Lymphatic malformations are benign vascular lesions that arise from embryological disturbances in the development of the lymphatic system. They encompass a wide spectrum of related abnormalities, including cystic lymphatic lesions, angiokeratoma, lymphatic malformations that occur in bones (Gorham-Stout Syndrome), lymphatic and chylous leak conditions, and(More)
The recent popularity of 3D IC technology stems from its enhanced performance capabilities and reduced wirelength. However, wire congestion and thermal issues are exacerbated due to the compact nature of these layered technologies. In this paper, we develop techniques to reduce the maximum temperature and wire congestion of 3D circuits without compromising(More)
OBJECTIVE Lymphatic malformations cause significant symptoms and functional deficits. Patients seek care for functional and symptomatic effects of their disease, but current disease burden and treatment outcome measures focus primarily on anatomy and histopathology. The authors describe disease impacts reported by patients and parents as a step toward more(More)
In this paper, we propose a new technique to accurately decompose process variation into two different components: (1) spatially correlated variation, and (2) uncorrelated random variation. Such variation decomposition is important to identify systematic variation patterns at wafer and/or chip level for process modeling, control and diagnosis. We(More)
The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 15-22 cm, which limits sensitivity and renders applications such as whole-body dynamic imaging or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the(More)