Karren Carmen Wong

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Mammary epithelial stem cells are vital to tissue expansion and remodeling during various phases of postnatal mammary development. Basal mammary epithelial cells are enriched in Wnt-responsive cells and can reconstitute cleared mammary fat pads upon transplantation into mice. Lgr5 is a Wnt-regulated target gene and was identified as a major stem cell marker(More)
Progesterone receptor (PR) expression and regulation of neural progenitor cell (NPC) proliferation was investigated using NPC derived from adult rat brain. RT-PCR revealed that PRA mRNA was not detected in rat NPCs, whereas membrane-associated PRs, PR membrane components (PGRMCs) 1 and 2, mRNA were expressed. Progesterone-induced increase in(More)
Review of 20 cases of congenital dilatation of the common bile duct in childhood showed an association with anomalous choledocho-pancreatic junction in 8. Study of human fetuses showed that the choledocho-pancreatic junction was outside the wall of the duodenum before 8 wk gestation and moved inward and towards the duodenal lumen as age advanced. Arrest of(More)
Purpose/Objectives: As concomitant chemoradiation followed by esophagectomy has become standard treatment for locally advanced esophageal cancer, there has been increasing emphasis on identifying a reliable imaging modality to assess treatment response. Given the high false negative and false positive findings with 18F-FDG-PET in the post-treatment setting,(More)
To investigate whether chronic hypokalemia increases the occurrence of dysrhythmias during anesthesia, the authors recorded the intraoperative electrocardiograms of normokalemic (K+ = 5.0 -3.5 mEq/l; N = 88) and chronically hypokalemic patients (K+ = 3.4 - 2.6 mEq/l; N = 62). In each patient, serum potassium was measured and a 12-lead ECG was analyzed prior(More)
To study the potential contribution of glycine toxicity in the transurethral resection syndrome, we evaluated hemodynamic and visual evoked potential responses to glycine infusion (1 g/kg) in 22 dogs anesthetized with halothane (1.0-1.2% end tidal. Three dogs received 5% glucose in normal saline without glycine; three received arginine (4 mg/kg) in normal(More)
Visual impairment or even transient blindness can result from transurethral resection of the prostate when glycine is used as the irrigating fluid. Electroretinograms were obtained from patients in the anesthetic preparation area and in the recovery room immediately after surgery. Four patients reported visual aberrations ranging from a "gray darkening" to(More)
Complications of transurethral resection of the prostate (TURP syndrome) when glycine is used as the irrigating fluid include cardiovascular and central nervous system abnormalities that occasionally include transient blindness. Serum sodium, glycine, potassium, chloride, ammonia, osmolality, carbonate, and blood urea nitrogen of 17 patients having TURP and(More)
Previously we developed an estrogen receptor β-selective phytoestrogenic (phytoSERM) combination, which contains a mixture of genistein, daidzein, and racemic R/S-equol. The phytoSERM combination was found neuroprotective and non-feminizing both in vitro and in vivo. Further, it prevented or alleviated physical and neurological changes associated with human(More)