Karolina M Nowak

Learn More
The maintenance of neural circuit stability is a dynamic process that requires the plasticity of many cellular and synaptic components. By changing the excitatory/inhibitory balance, inhibitory GABAergic plasticity can regulate excitability, and contribute to neural circuit function and refinement in learning and memory. Increased inhibitory GABAergic(More)
Helleborus is a valuable ornamental plant, flowering in early spring or winter. Its hybrid cultivars can be propagated vegetatively, including in vitro via axillary shoots. One of the obstacles preventing effective micropropagation is the necessity for culture to be kept at a temperature of around 15oC, which additionally increases costs. Knowledge obtained(More)
Ketamine, phencyclidine and MK801 are uncompetitive NMDA receptor (NMDAR) antagonists which are used widely to model certain features of schizophrenia in rats. Systemic administration of NMDAR antagonists, in addition to provoking an increase in c-Fos expression, leads to important neurochemical and electrophysiological changes within the medial prefrontal(More)
During organic contaminant degradation in soil, bound or nonextractable residues (NER) are formed. Part of these residues may be biogenic, because degrading microorganisms assimilate carbon derived from the pollutant and mineralized CO(2) to form cellular components for example, [fatty acids (FA) and amino acids (AA)], which are subsequently stabilized(More)
The persistence of chemicals is a key parameter for their environmental risk assessment. Extrapolating their biodegradability potential in aqueous systems to soil systems would improve the environmental impact assessment. This study compares the fate of (14/13)C-labelled 2,4-D (2,4-dichlorophenoxyacetic acid) and ibuprofen in OECD tests 301 (ready(More)
Non-extractable residues (NER) formed during biodegradation of organic contaminants in soil are considered to be mainly composed of parent compounds or their primary metabolites with hazardous potential. However, in the case of biodegradable organic compounds, the soil NER may also contain microbial biomass components, for example fatty acids (FA) and amino(More)
AIMS The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS Twenty PD MCI and 31 PD non-MCI patients (mean(More)
Adsorption kinetics of zearalenone (ZEA) toxin from synthetic gastric fluid (SGF) and synthetic body fluid (SBF) by talc and diatomite was studied in the batch experiments. Chemical composition, morphology and structure of the used adsorbents were examined by scanning electron microscopy, FTIR spectroscopy and low-temperature nitrogen adsorption/desorption(More)
Quantification of nonextractable residues (NER) of pesticides in soil is feasible by use of radioactively labeled compounds, but structural information on these long-term stabilized residues is usually lacking. Microorganisms incorporate parts of the radiolabeled ((14)C-) carbon from contaminants into microbial biomass, which after cell death enters soil(More)