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MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility.

• Radoslaw Polański, Maria Maguire, +8 authors Mark T. Boyd
• Carcinogenesis
• 2011

MDM2 expression, combined with increased p53 expression, is associated with reduced survival in several cancers, but is particularly of interest in renal cell carcinoma (RCC) where evidence suggests… (More)

5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors.

• Nicolas Boutard, Aleksandra Sabiniarz, +23 authors Piotr Kowalczyk
• Bioorganic & medicinal chemistry letters
• 2019

Maternal embryonic leucine zipper kinase (MELK) is involved in several key cellular processes and displays increased levels of expression in numerous cancer classes (colon, breast, brain, ovary,… (More)

Abstract B242: Antitumor activity of SEL120: An orally available small-molecule inhibitor of Haspin kinase for standalone and combination therapy with AuroraB inhibitors in colorectal cancer.

• Tomasz Rzymski, Adrian Zarębski, +11 authors Krzysztof Brzózka
• 2011

The mitotic machinery is a validated target for potential drug therapies in cancer. Anti-mitotic drugs like vinca alkaloids and taxanes interfering with microtubules are important classes of… (More)

Abstract A243: Novel Pim kinase inhibitors for treatment of hematological malignancies and solid tumors.

• Krzysztof Brzózka, Aleksandra Sabiniarz, +14 authors Nicolas Beuzen
• 2011

The family of Pim kinases emerged as a novel and interesting target with significant potential for therapeutic intervention in cancer. All three members of the family Pim-1, Pim-2 and Pim-3 were… (More)

O naszych dzieciach i reformie szkolnictwa

• Karolina Krawczyńska
• 1999

516 Development of Selective PIM Kinase Inhibitors for Cancer Treatment

• Krzysztof Brzózka, Renata Windak, +7 authors Wojciech Czardybon
• 2012

Perception of safety of urban residents

• Beata Czuba, Karolina Krawczyńska
• 2018

Abstract 2160: Development of selective MELK kinase inhibitors for cancer treatments.

• Piotr Kowalczyk, Paulina Węgrzyn, +7 authors Krzysztof Brzózka
• 2013

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Maternal embryonic leucine zipper kinase (MELK) is an atypical member of the AMPK family of serine-threonine kinases that… (More)

Abstract 3245: Identification of potent, dual PIM/FLT3 kinase inhibitors for AML treatment.

• Wojciech Czardybon, Michał Gałęzowski, +12 authors Krzysztof Brzózka
• 2013

518 Development of Selective CDK8 Inhibitors for Colorectal Cancer Treatment

• Krzysztof Brzózka, Adrian Zarębski, +7 authors Tomasz Rzymski
• 2012

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