Karolien Billion

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TorsinA (also known as torsin-1A) is a membrane-embedded AAA+ ATPase that has an important role in the nuclear envelope lumen. However, most torsinA is localized in the peripheral endoplasmic reticulum (ER) lumen where it has a slow mobility that is incompatible with free equilibration between ER subdomains. We now find that nuclear-envelope-localized(More)
TorsinA is a membrane-embedded AAA+ ATPase important in the nuclear envelope (NE) lumen. However, most torsinA is localized in the peripheral endoplasmic reticulum (ER) lumen with slow mobility incompatible with free equilibration between ER subdomains. We now find that NE-localized torsinA is on the inner nuclear membrane (INM) and ask how torsinA reaches(More)
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