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This study was initiated to develop an animal model of type 2 diabetes in a non-obese, outbred rat strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of(More)
An ethnomedically-driven approach was used to evaluate the ability of a pure compound isolated from the creosote bush (Larrea tridentata) to lower plasma glucose concentration in two mouse models of type 2 diabetes. The results indicated that plasma glucose concentration fell approximately 8 mmol/l in male C57BL/ks-db/db or C57BL/6J-ob/ob mice following the(More)
LPS-binding protein (LBP) mediates the pro-inflammatory effects of bacterial LPS by enhancing LPS-induced cytokine production by monocytic cells. LBP binds specifically to LPS to generate a complex that interacts with the CD14 receptor on the surface of responsive cells. To identify the biologically active regions of the protein responsible for mediating(More)
A simple graph G is k-ordered (respectively, k-ordered hamiltonian), if for any sequence of k distinct vertices v 1 ,. .. , v k of G there exists a cycle (respectively, hamiltonian cycle) in G containing these k vertices in the specified order. In 1997 Ng and Schultz introduced these concepts of cycle orderability and posed the question of the existence of(More)
Glucose metabolism of respiratory and nonrespiratory muscles of different fiber composition was investigated in conscious rats. The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% at 3 h after treatment with 100 micrograms/100 g endotoxin. The increase was still marked at 24 h,(More)
A simple graph G is k-ordered (respectively, k-ordered hamiltonian) if, for any sequence of k distinct vertices v 1 ,. .. , v k of G, there exists a cycle (respectively, a hamiltonian cycle) in G containing these k vertices in the specified order. In 1997 Ng and Schultz introduced these concepts of cycle orderability, and motivated by the fact that(More)
We give a bijection between permutations of 1,. .. , 2n and certain pairs of Dyck paths with labels on the down steps. The bijec-tion arises from a game in which two players alternate selecting from a set of 2n items: the permutation encodes the players' preference ordering of the items, and the Dyck paths encode the order in which items are selected under(More)
Glucose utilization of different organs (spleen, liver, ileum, kidney, skin, lung, and testis) was investigated in vivo in conscious rats 3, 24, or 48 h after treatment with 100 micrograms of endotoxin/100 g of body weight. Glucose uptake was determined by the 2-deoxyglucose technique, which was validated by demonstrating that endotoxin treatment did not(More)
Infiltration of polymorphonuclear neutrophils (PMN) in the rat liver 3 hr after an intravenous (IV) injection of a sublethal dose of Escherichia coli lipopolysaccharide (LPS) was observed without any significant alteration in the total number of Kupffer and endothelial cells. Since previous studies have demonstrated that phagocytic cells in the liver were(More)