Karmela A. Ramos

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Ceramides and sphingoid long-chain bases (LCBs) are precursors to more complex sphingolipids and play distinct signaling roles crucial for cell growth and survival. Conserved reactions within the sphingolipid biosynthetic pathway are responsible for the formation of these intermediates. Components of target of rapamycin complex 2 (TORC2) have been(More)
SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that focused on the well-sumoylated substrate, human Liver Receptor Homolog-1 (hLRH-1, NR5A2). Our primary(More)
Department of Cellular and Molecular Pharmacology, 9 Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, 10 Department of Biochemistry and Biophysics 11 Department of Epidemiology and Biostatistics, 12 University of California, San Francisco, 13 San Francisco, California 94158, USA 14 Chemical Biology Laboratory 15 National Cancer(More)
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