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OBJECTIVE To evaluate the effect of prolonged partial liquid ventilation with perflubron (partial liquid ventilation), using conventional and high-frequency ventilatory techniques, on gas exchange, hemodynamics, and lung pathology in an animal model of lung injury. DESIGN Prospective, randomized, controlled study. SETTING Animal laboratory of the Infant(More)
The presence of rheumatoid arthritis in patients undergoing 111indium-labelled polymorphonuclear leucocyte scanning represents a source of possible diagnostic confusion. In such patients, the labelled cells frequently accumulate over the caecum and ascending colon, despite the absence of obvious pathology of the large bowel. The aetiology of this effect is(More)
The tension-free vaginal tape (TVT) procedure is recognised as an effective treatment for genuine stress incontinence. It was first described using local anaesthesia, with an intra-operative cough test helping to correctly position the tape. Many patients prefer general anaesthesia and often, patients with genuine stress incontinence do not leak when(More)
We compared the effects of surfactant and partial liquid ventilation (PLV), and the impact of administration order, on oxygenation, respiratory system compliance (Crs), hemodynamics, and lung pathology in an animal lung injury model. We studied four groups: surfactant alone (S; n = 8); partial liquid ventilation alone (PLV-only; n = 8); surfactant followed(More)
OBJECTIVE To test the hypothesis that high-frequency ventilation (HFV), when compared with conventional techniques, enhances respiratory gas exchange during partial liquid ventilation (PLV). DESIGN A four-period crossover design. SETTING Animal research laboratory of Children's Health Care-St. Paul. SUBJECTS Thirty-two newborn piglets, weighing 1.40(More)
BACKGROUND Patients with idiopathic Parkinson's disease (PD) or atypical Parkinsonism (AP) often present with orthostatic hypotension (OH) as a result of the dysautonomia associated with the disease or as a side effect of the dopaminergic medications used to treat it. Our recent study suggested that OH negatively impacts gross motor, balance, and cognitive(More)
OBJECTIVE We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN We used a four-period crossover design. Each patient(More)
In a laboratory trial chickens were given immunising doses of six species of Eimeria when they were 2 weeks of age and the effect of medication with monensin or arprinocid from 0-10 weeks was determined by challenge inoculation. Monensin in the food at 60-100 ppm resulted in depression of immunity but concentrations of 40-50 ppm only slightly affected(More)
OBJECTIVE To test the hypothesis that perfluorocarbon (PFC) priming before surfactant administration improves gas exchange and lung compliance, and also decreases lung injury, more than surfactant alone. DESIGN Prospective, randomized animal study. SETTING Animal research laboratory of Children's Hospital of St. Paul. SUBJECTS Thirty-two newborn(More)