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The dioxin receptor is a ligand-activated transcription factor with multiple functions in xenobiotic metabolism, development and dioxin toxicity. The focus here is on its roles in regulating endo- and xenobiotic conjugation by UDP-glucuronosyltransferases, and in dioxin-mediated cancer progression. Dioxins are poorly metabolized leading to sustained… (More)
Bilirubin, the product of heme catabolism, represents an important endobiotic of the endo-and xenobiotic metabolism system including drug-metabolizing enzymes, drug transporters, and drug-inducible ligand-activated transcription factors (LATFs). Bilirubin is of clinical concern since severe neonatal jaundice may lead to " kernicterus " and neurotoxicity… (More)