Karl Scheffer

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1. The effects of the Mg complex of adenosine 5'-triphosphate (MgATP) on binding of sulphonylureas to microsomes obtained from mouse pancreatic islets were examined. 2. MgATP inhibited the binding of both glibenclamide and tolbutamide to microsomes. 3. Binding of [3H]-glibenclamide inhibited by MgATP was not further diminished by Mg(2+)-bound adenosine(More)
The patch-clamp technique was used to examine the tolbutamide-sensitivity of the adenosine 5′-triphosphate (ATP)-dependent K+ channel in mouse pancreatic B-cells. When studied at 37°C in cell-attached membrane patches, this channel had a single-channel conductance of 88 pS and was half-maximally inhibited by 2.2 μmol/l tolbutamide in the presence of 3(More)
The effectiveness of orally administered iron was investigated using three different iron preparations in a randomized study with 3 patient groups, each consisting of 20 subjects with iron deficiency anaemia. Group A received a ferric(III)-dextrin complex, group B Fe(II)-sulfate, and group C Fe(II)-fumarate with vitamins. For all three preparations the(More)
A low-power multi-standard transceiver in CMOS 28 nm is presented. The transceiver can be configured to cover the range from 5 Gbps to 28.2 Gbps. Both transmitter and receiver use a supply of 0.92 V. Transmitter uses a 3-tap Finite Impulse Response (FIR) filter and receiver uses a 3-tap analog FIR and 2-tap unrolled Decision Feedback Equalizer (DFE). The(More)
A double-blind study was carried out in 54 patients requiring iron therapy to compare the effects of orally administered bivalent and trivalent iron over a period of 12 weeks. Patients were allocated at random to receive ferrous sulphate (100 mg/day), ferritin (80 mg/day as Fe3+) or a combination of ferritin (80 mg Fe3+/day), folinic acid and vitamin B12(More)
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