Karl Richard Bruckdorfer

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BACKGROUND It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease. OBJECTIVES The objective was to examine the associations between dietary and plasma vitamin C concentrations, fruit and vegetable intakes, and markers of inflammation and hemostasis associated with(More)
BACKGROUND Fresh fruit consumption and vitamin C intake have been associated with improved lung function in adults. Whether this is due to enhancement of lung growth, to a reduction in lung function decline, or to protection against bronchospasm is unclear. METHODS In a cross-sectional school based survey of 2650 children aged 8-11 from 10 towns in(More)
Dietary nitrate is metabolized to nitrite by bacterial flora on the posterior surface of the tongue leading to increased salivary nitrite concentrations. In the acidic environment of the stomach, nitrite forms nitrous acid, a potent nitrating/nitrosating agent. The aim of this study was to examine the pharmacokinetics of dietary nitrate in relation to the(More)
Premature atherosclerosis is a major cause of morbidity and mortality in chronic renal failure (CRF). Endothelial dysfunction is a key early event in atherogenesis. The aim of this study was to assess the effect of CRF on endothelial function using physiological and biochemical measures. To focus on the effect of CRF itself, 23 children (matched with 23(More)
a , a b c b c * J.Y. Jeremy , G.D. Angelini , M. Khan , D.P. Mikhailidis , R.J. Morgan , C.S. Thompson , d e K.R. Bruckdorfer , K.M. Naseem Department of Cardiac Surgery, Division of Cardiac, Anaesthetic and Radiological Sciences, Bristol Royal Infirmary, Bristol BS2 8HW, UK Department of Urology, Royal Free Hospital and School of Medicine, London, UK(More)
OBJECTIVES Endothelial dysfunction is a primary event in systemic sclerosis; however, the aetiology of events and the role of nitric oxide (NO) is still unclear. The aim of the present study is to investigate whether there are abnormalities in NO metabolism in plasma from patients with primary Raynaud's phenomenon (RP) and in the pathogenesis of systemic(More)
OBJECTIVE To examine the resistance to oxidation of low-density lipoproteins (LDL) from patients with systemic sclerosis (SSc) and primary Raynaud's phenomenon (RP) compared with healthy controls. METHODS Plasma LDL were isolated from patients with diffuse cutaneous and limited cutaneous SSc (dcSSc and lcSSc, respectively), patients with primary RP, and(More)
Nitric oxide ((.-)NO) is an important physiological signaling molecule and potent vasodilator. Recently, we have shown abnormal (.-)NO metabolism in the plasma of patients with systemic sclerosis (SSc), a disease that features excessive collagen overproduction as well as vascular dysfunction. The current study investigates the effects of (.-)NO and(More)
SYSTEMIC SCLEROSIS (SCLERODERMA: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One of the most important and early modulators of disease activity(More)
Fourteen young male volunteers measured their habitual dietary intake for 2 weeks, then were told to increase their dietary sucrose while decreasing their other carbohydrates for 2 weeks and finally told to revert to their habitual diet while continuing to record their intake. Measurement of plasma constituents revealed a significant fall in HDL-cholesterol(More)