Karl Persson

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Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially(More)
Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, INSERM U1081, University of 7 Nice Sophia Antipolis, Nice, France. 8 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom. 9 Department of Chemistry and Molecular Biology, Gothenburg University, Gothenburg 40530, Sweden 10 Sorbonne Universités, UPMC Univ. Paris(More)
We have previously shown that ethylene production in Saccharomyces cerevisiae expressing the ethylene-forming enzyme (EFE) from Pseudomonas syringae is strongly influenced by variations in the mode of cultivation as well as the choice of nitrogen source. Here, we have studied the influence of nitrogen metabolism on the production of ethylene further. Using(More)
The detrimental effect of the petroleum industry on the environment combined with the threat of peak oil has driven the exploration for alternative strategies to produce traditional petrochemicals. Biotechnological production could be an alternative, using microorganisms to convert renewable feedstocks into desired products. A microbial based system for(More)
Ethylene is one of the most used chemical monomers derived from non-renewable sources and we are investigating the possibility of producing it in yeast via the ethylene forming enzyme (EFE) from Pseudomonas syringae. To enable engineering strategies to improve the enzyme, it is necessary to identify the regions and amino acid residues involved in ethylene(More)
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