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BACKGROUND Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of onset. The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to 6 h from stroke onset. METHODS In this international, multicentre, randomised,(More)
BACKGROUND AND PURPOSE Acute-onset dysphagia after stroke is frequently associated with an increased risk of aspiration pneumonia. Because most screening tools are complex and biased toward fluid swallowing, we developed a simple, stepwise bedside screen that allows a graded rating with separate evaluations for nonfluid and fluid nutrition starting with(More)
OBJECTIVE To determine the prevalence of disturbances in glucose metabolism in patients with acute stroke. RESEARCH DESIGN AND METHODS Consecutively admitted acute stroke patients (n = 286) were screened for glucose tolerance according to the standardized World Health Organization protocol in the 1st and 2nd week after the stroke event. In addition, we(More)
BACKGROUND Intravenous recombinant tissue plasminogen activator (rt-PA) is approved for use in selected patients with ischaemic stroke within 3 hours of symptom onset. IST-3 seeks to determine whether a wider range of patients may benefit. DESIGN International, multi-centre, prospective, randomized, open, blinded endpoint (PROBE) trial of intravenous(More)
BACKGROUND Intravenous recombinant tissue plasminogen activator (rtPA) is approved in Europe for use in patients with acute ischaemic stroke who meet strictly defined criteria. IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to(More)
Alien hand syndrome (AHS) is rare, but important due to its disabling impact on everyday life. The determining characteristic of AHS is intermanual conflict, a type of inhibitory motor behaviour that occurs against willed action. Its components have previously been described as single case reports, but not as a systematic study. This review includes eight(More)
PURPOSE Aim was to assess the frequencies of electrocardiographic (ECG) abnormalities, including QT prolongation, in acute stroke patients and their association with stroke severity, stroke subtype and location, and cardiovascular risk factors. METHODS Prospectively, admission 12-lead ECG findings, stroke characteristics, cardiovascular risk factors, and(More)
BACKGROUND AND PURPOSE Cognitive impairment occurs in ≤30% of all stroke survivors. However, effective therapies aimed at preventing poststroke cognitive decline are lacking. We assessed the efficacy of a multidomain intervention on preventing cognitive decline after stroke. METHODS In this randomized, observer-blind trial patients were recruited within 3(More)
BACKGROUND AND PURPOSE Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke(More)
OBJECTIVE: In the preclinical phase of stroke care there are still many uncertainties. One of them includes the decision on which side to lay an acute stroke victim until professional help arrives and the patient is transported to hospital. METHODS AND RESULTS: This controlled study aimed at finding possible advantages of laying the patient on the paretic(More)