Karl Matthias Haslbeck

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OBJECTIVES Binding of ligands to the receptor for advanced glycation end products (RAGE) results in activation of the transcription factor NF-kappaB and subsequent expression of NF-kappaB regulated cytokines and is a possible pathomechanism in diabetic and in vasculitic polyneuropathies (PNP). We wanted to investigate whether the newly discovered RAGE(More)
Increased oxidative stress and advanced glycosylation are important factors in the development of diabetic neuropathy. In non-diabetic neuropathies their influence has not been investigated in detail so far. We studied the localisation of N ε-carboxymethyllysine (CML) – a biomarker for oxidative stress – by immunohistochemistry in sural nerve biopsies of 31(More)
Oxidative stress and nuclear factor-κB (NF-κB) activation are linked to the pathogenesis of many metabolic, degenerative, and chronic inflammatory diseases. Activation of the receptor for advanced glycation end products (RAGE) by its specific ligand Nε-carboxymethyllysine (CML) results in the activation of NF-κB and the production of proinflammatory(More)
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