Karl Matthias Haslbeck

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OBJECTIVES Binding of ligands to the receptor for advanced glycation end products (RAGE) results in activation of the transcription factor NF-kappaB and subsequent expression of NF-kappaB regulated cytokines and is a possible pathomechanism in diabetic and in vasculitic polyneuropathies (PNP). We wanted to investigate whether the newly discovered RAGE(More)
OBJECTIVE To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans. BACKGROUND Recently, it has been shown that VNS has antinociceptive and antidepressant effects in humans. METHODS Eleven patients were investigated before (baseline) and during chronic VNS treatment. The experiments were performed at two different stimulation(More)
Increased oxidative stress and advanced glycosylation are important factors in the development of diabetic neuropathy. In non-diabetic neuropathies their influence has not been investigated in detail so far. We studied the localisation of N(epsilon)-carboxymethyllysine (CML) - a biomarker for oxidative stress - by immunohistochemistry in sural nerve(More)
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