Karl Kevin Cuddy

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Osteoclastogenesis (OCG) results from the fusion of monocytes after stimulation with macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). Migration of monocytes into close proximity precedes critical fusion events that are required for osteoclast formation. Cellular migration requires leading-edge actin(More)
Shwachman-Diamond syndrome (SDS) results from mutations in the SBDS gene, characterized by exocrine pancreatic insufficiency and hematologic and skeletal abnormalities. Neutropenia and neutrophil dysfunction are hallmark features of SDS; however, causes for the bone defects are unknown. Dysfunction of bone-resorbing osteoclasts, formed by the fusion of(More)
Micro-liquid chromatography-mass spectrometry (micro-LC-MS) was utilized to quantitatively determine betamethasone and its major unconjugated metabolite, 6 beta-hydroxybetamethasone, in equine plasma and urine. The advantage of micro-LC-MS over conventional gas chromatography-mass spectrometry in corticosteroid determination is illustrated and the reliable,(More)
BACKGROUND Oral, lip and oropharyngeal cancer accounts for up to 75% of head and neck cancers. Dental professionals contribute to improved treatment outcomes through early detection of these cancers. Oral and maxillofacial surgeons (OMFS) are trained to participate in numerous phases of care for patients with oral, lip and oropharyngeal cancer. OBJECTIVE(More)
PURPOSE Virtual surgical planning (VSP) is an indispensable aid in craniomaxillofacial reconstruction, yet no protocol is established in facial gunshot wounds. We review our experience with computer-aided reconstruction of self-inflicted facial gunshot wounds (SIGSW'S) and propose a protocol for the staged repair. METHODS A retrospective case series(More)
Thromb Haemost 2006; 96: 387–9 Dear Sir, In patients who undergo major orthopedic surgery with spinal/ epidural anesthesia, continuous epidural analgesia (CEA) can be given for postoperative analgesia (1–3). In such patients who are at high risk for postoperative deep vein thrombosis (4), the initiation of low-molecular-weight heparin (LMWH) for(More)
PURPOSE The purpose of this study was to assess the participation of Canadian oral and maxillofacial surgeons (OMSs) in the various phases of oral, lip, and oropharyngeal cancer care. MATERIALS AND METHODS A survey was conducted to quantify participation in oral, lip, and oropharyngeal cancer care and assess participation ranging from screening for(More)
  • Mark Roger Darling, Rebecca Woodford, +5 authors Zia Khan
  • Journal of investigative and clinical dentistry
  • 2017
AIM The aim of the present study was to profile the expression of human kallikrein (KLK)-related peptidases (KLK) in odontogenic lesions. METHODS Paraffin-embedded, formalin-fixed, non-odontogenic (control) and odontogenic lesions were stained for KLK using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained(More)
HD1, a DNA aptamer, binds exosite 1 on thrombin and blocks its clotting activity. Because HD1 also binds prothrombin and inhibits its activation by prothrombinase, we hypothesised that HD1 would be a more potent inhibitor of coagulation than other exosite 1-directed ligands, such as Hir(54-65)(SO(3)(-)). Supporting this concept, the effect of HD1 on the(More)